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VOLUME 40 , ISSUE 4ESP ( Aug-2012, 2012 ) > List of Articles

REVIEW ARTICLE

Indicaciones y Tiempo Apropiado para el Cross-Linking

Efekan Coskunseven, Mirko R. Jankov, Ali Kerem Yurtsever, Farhad Hafezi

Citation Information : Coskunseven E, Jankov MR, Yurtsever AK, Hafezi F. Indicaciones y Tiempo Apropiado para el Cross-Linking. 2012; 40 (4ESP):2-8.

DOI: 10.5005/hos-10101-40401

Published Online: 24-09-2020

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.


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  1. Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res 1998;66:97-103
  2. Wollensak G, Spoerl E, Seiler T. Riboflavin/Ultraviolet-A induced collagen cross-linking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620-7.
  3. Kohlhaas M, Spoerl E, Speck A, Schilde T, Sandner D, Pillunat LE. A new treatment of keratectasiaafter LASIK with riboflavin/UVA light cross-linking. Klin Monatsbl Augenheilkd 2005; 222:430-6.
  4. Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: Preliminary refractive results in an Italian study. J Refract- Surg 2006;32:837-45.
  5. Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C, et al. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: Ultra structural analysis by heidelberg retinal tomograph II in vivo con focal microscopy in humans. Cornea 2007;26:390-7.
  6. Coskunseven E, Jankov MR, Hafezi F. Comparative study of corneal collagen cross linking with Riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg 2009;25:371-6.
  7. Jankov MR, Hafezi F, Beko M, Ignjatovic Z, Djurovic B, Markovic V, et al. Ultra B2 - promoção de ligações covalentes do colágeno cornea (corneal cross-linking) no tratamento de cerato cone: Resultados preliminares. Arq Bras Oftalmol 2008;71:813-8.
  8. Agrawal VB. Corneal collagen cross-linking with riboflavin and ultraviolet: A light for keratoconus: Results in Indian eyes. Indian J Ophthalmol 2009;57:111-4.
  9. Wittig-Silva C, Whiting M, Lamoureux E, Lindsav RG, Sulivan IJ, Snibson GR. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: Preliminary results. J Refract Surg 2008;24:S720-5
  10. Vinciguerra P, Albe E, Trazza S, Rosetta P, Vinciguerra R, Seiler T, et al. Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross- linking. Ophthalmology 2009;116:369-78.
  11. Hafezi F, Wiltfang R, Kanellopoulos J, Seiler T. Corneal collagen cross-linking with riboflavin/UVA for the treatment of induced keratectasia after laser in situ keratomileusis. J Cat Refract Surg 2007;33:2035-40.
  12. Vinciguerra P, Camesasca FI, Albe E, Trazza S. Corneal collagen cross-linking for ectasia after excimer laser refractive surgery: 1-year results. J Refract Surg 2009;1-12.
  13. Schnitzler E, Sporl E, Seiler T. Irradiation of cornea with ultra violet light and riboflavin administration as a new treatment for erosive corneal processes, preliminary results in four patients. Klin Monatsbl Augenheilkd 2000;217:190-3.
  14. Schrier A, Greebel G, Attia H, Trokel S, Smith EF. In vitro antimicrobial efficacy of riboflavin and ultraviolet light on Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa. J Refract Surg 2009;25:S799-802.
  15. Wollensak G, Aurich H, Wirbelauer C, Pham DT. Potential use of riboflavin/UVA cross-linking in bullous keratopathy. Ophthalmic Res 2009;41:114-7.
  16. Ehlers N, Hjortdal J, Nielsen K, Søndergaard A. Riboflavin-UVA treatment in the management of edema and non healing ulcers of the cornea. J Refract Surg 2009;25:S803-6.
  17. Ehlers N, Hjortdal J. Riboflavin-ultra violet light induced cross-linking in endothelial decompensation. Acta Ophthalmol 2008;86:549-51.
  18. Zamora KV, Males JJ. Polymicrobial keratitis after a collagen cross-linking procedure with postoperative use of a contact lens: A case report. Cornea 2009;28:474-6.
  19. Krueger RR, Ramos-Esteban JC, Kanellopoulos AJ. Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullous keratopathy: Laboratory investigation and first clinical case. J Refract Surg 2008;24:S730-6.
  20. Iseli HP, Thiel MA, Hafezi F, Kampmeier J, Seiler T. Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts. Cornea 2008;27:590-4.
  21. Coskunseven E, Jankov MR 2nd, Hafezi F, Atun S, Arslan E, Middle East African Journal of Ophthalmology, Volume 17, Number 1, January - March 2010 27Jankov II, et al.: Corneal Collagen Cross-linking Kymionis GD. Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen cross-linking for keratoconus. Cataract Refract Surg 2009;35:2084-91.
  22. Kamburoglu G, Ertan A. Intacs implantation with sequential collagen cross-linking treatment in postoperative LASIK ectasia. J Refract Surg 2008;24:S726-9.
  23. Chan CC, Sharma M, Wachler BS. Effect of implantation of inferior-segment Intacs with and without C3-R on keratoconus. J Cataract Refract Surg 2007;33:75-80.
  24. Kanellopoulos AJ, Binder PS. Collagen cross-linking (CCL) with sequential topography- guided PRK: A temporizing alternative for keratoconusto penetrating keratoplasty. Cornea 2007;26:891-5.
  25. Kymionis GD, Kontadakis GA, Kounis GA, Portaliou DM, Karavitaki AE, Magarakis M, et al. Simultaneous topography guided PRK followed by corneal collagen cross-linking for keratoconus. J Refract Surg 2009;25:S807-11.
  26. Raiskup F, Hoyer A, Spoerl E. Permanent corneal haze after riboflavin-UVA-induced cross- linking in keratoconus. J Refract Surg 2009;25:S824-8.
  27. Kymionis GD, Bouzoukis DI, Diakonis VF, Portaliou DM, Pallikaris AI, Yoo SH. Diffuse lamellar keratitis after corneal cross-linking in a patient with post-laser in situ keratomileusis corneal ectasia. J Cataract Refract Surg 2007;33:2135-7.
  28. Kymionis GD, Portaliou DM, Bouzoukis DI, Suh LH, Pallikaris AI, Markomanolakis M, et al. Herpetic keratitis with iritis after corneal cross-linking with riboflavin and ultraviolet A for keratoconus. J Cataract Refract Surg 2007;33:1982-4.
  29. Koppen C, Vryghem JC, Gobin L, Tassignon MJ. Keratitis and corneal scarring after UVA/riboflavin cross-linking
  30. Kathleen Loouden, Corneal Cross-Linking in Children With Keratoconus Improves Visual Acuity, American Academy of Ophthalmology (AAO) and Middle East Africa- Council of Ophthalmology (MEACO) 2010 Joint Annual Meeting
  31. Wollensak G, Spoerl E, Reber F, Seiler T. Keratocyte cytotoxicity of riboflavin/UVA treatmentin vitro. Eye 2004;:1-5.
  32. Wollensak G, Spoerl E, Wilsch M, Seiler T. Keratocyte apoptosis after corneal collagen cross- linking using Riboflavin/UVA treatment. Cornea 2004;23:43-9.
  33. Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin-ultraviolet: A treatment in the rabbit. J Cataract Refract Surg 2003;29:1786-90.
  34. Seiler T, Hafezi F. Corneal cross-linking-induced stromal demarcation line. Cornea 2006;25:1057-9.
  35. Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C, et al. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: Ultra structural analysis by Heidelberg Retinal Tomograph II in vivo con focal microscopy in humans. Cornea 2007;26:390-7.
  36. Eberhard Spoerl, PhD,* Michael Mrochen, PhD,† David Sliney, PhD, Stephen Trokel, MD,§ and Theo Seiler, MD, PhD† Safety of UVA-Riboflavin Cross-Linking of Cornea Cornea Volume 26, Number 4, May 2007 14
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