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VOLUME 41 , ISSUE 2ENG ( Apr-2013, 2013 ) > List of Articles


Stage IVE Non-Hodgkin Lymphoma Presenting Solely as Swelling of the Lids and Conjunctiva

A. Ibraheim, M. Dogramaci

Citation Information : Ibraheim A, Dogramaci M. Stage IVE Non-Hodgkin Lymphoma Presenting Solely as Swelling of the Lids and Conjunctiva. 2013; 41 (2ENG):6-7.

DOI: 10.5005/hoo-10101-41202

Published Online: 01-10-2020

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


PURPOSE: To describe unusual case of aggressive stage IVE1 non- Hodgkin lymphoma involving extensively the sinonasal tract but presenting for the first time with acute swelling of the lids and conjunctiva with vertical diplopia without any other systemic signs and symptoms. DESIGN: Observational case report. METHOD: 78 years old male was referred with 10 days duration of swollen lids conjunctiva, watering right eye and vertical diplopia. RESULTS: The patient was found to have high grade Large B cells non-Hodgkin's lymphoma involving the maxillary, frontal, ethmoidal sinuses, erosion of the bony nasal septum, erosion of the orbital floor and extension into the orbit, large right and left axillary lymph nodes, and enlarged right mediastinal lymph nodes. CONCLUSION: Although rare but it is possible for the eye surgeon to be the first to diagnose many life threatening disease that starts somewhere in the body and just present solely as eye problem. An example of which is this reported case of extensive lymphoma. The patient has responded very well to urgent chemotherapy treatment and now is asymptomatic, with 100% recovery of the eye signs and symptoms as well as inducing remission of the whole disease process.

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  1. Tzankov A, Dirnhofer S. Pathobiology of classical Hodgkin lymphoma Pathobiology. 2006;73(3):107-25
  2. Source Canadian Cancer Statistic, National Cancer Institute of Canada 2004.
  3. Source American Cancer Society:
  4. Woo JM, Tang CK, Rho MS, Lee JH, Kwon HC, Ahn HB. The clinical characteristics and treatment results of ocular adnexal lymphoma. Korean J Ophthalmol. 2006 Mar;20(1):7-12.
  5. Nola M., Lukenda A., Bollmann M., Kalauz M, Petrovecki M, Bollmann R. Outcome and prognostic factors in ocular adnexal lymphoma Croat Med J. 2004 Jun;45(3):328-32.
  6. Peterson K, Gordon KB, Heinemann MH, DeAngelis LM. The clinical spectrum of ocular lymphoma. Cancer. 1993 Aug 1;72(3):843-9.
  7. Lee JL, Kim MK, Lee KH, Hyun MS, Chung HS, Kim DS, Shin SO, Cho HS Bae SH, Ryoo HM. Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue-type of the orbit and ocular adnexa Ann Hematol.2005 Jan;84(1):13-8. Epub 2004 Aug 10.
  8. Coupland SE, Hummel M., Stein H. Ocular adnexal lymphomas: five case presentations and a review of the literature. Surv Ophthalmol 2002 Sep- Oct;47(5):470-90.
  9. Auw-Haedrich, C Coupland, SE Kapp, A Schmitt-Graff, A Buchen, R Witschel, H Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. Revised European and American Lymphoma Br J Ophthalmol. 2001 Jan;85(1):63-9.
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