Highlights of Ophthalmology

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 40 , ISSUE 4ENG ( Aug-2012, 2012 ) > List of Articles


Cross-Linking Indications and Effective Timing

Efekan Coskunseven, Mirko R. Jankov, Ali Kerem Yurtsever, Farhad Hafezi

Citation Information : Coskunseven E, Jankov MR, Yurtsever AK, Hafezi F. Cross-Linking Indications and Effective Timing. 2012; 40 (4ENG):2-8.

DOI: 10.5005/hoo-10101-40401

Published Online: 24-09-2020

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.


PDF Share
  1. Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res 1998;66:97-103
  2. Wollensak G, Spoerl E, Seiler T. Riboflavin/Ultraviolet-A induced collagen cross linking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620-7.
  3. Kohlhaas M, Spoerl E, Speck A, Schilde T, Sandner D, Pillunat LE. A new treatment of keratectasiaafter LASIK with riboflavin/UVA light cross-linking. Klin Monatsbl Augenheilkd 2005;222:430-6.
  4. Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: Preliminary refractive results in an Italian study. J Refract-Surg 2006;32:837-45.
  5. Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C, et al. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: Ultra structural analysis by Heidelberg retinal tomograph II in vivo con focal microscopy in humans. Cornea 2007;26:390-7.
  6. Coskunseven E, Jankov MR, Hafezi F. Comparative study of corneal collagen cross- linking with Riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg 2009;25:371-6.
  7. Jankov MR, Hafezi F, Beko M, Ignjatovic Z, Djurovic B, Markovic V, et al. Ultra B2 - promoção de ligações covalentes do colágeno cornea (corneal cross linking) no tratamento de cerato cone: Resultados preliminares. Arq Bras Oftalmol 2008; 71:813-8.
  8. Agrawal VB. Corneal collagen cross-linking with riboflavin and ultraviolet: A light for keratoconus: Results in Indian eyes. Indian J Ophthalmol 2009;57:111-4.
  9. Wittig-Silva C, Whiting M, Lamoureux E, Lindsav RG, Sulivan IJ, Snibson GR. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: Preliminary results. J Refract Surg 2008;24:S720-5
  10. Vinciguerra P, Albe E, Trazza S, Rosetta P, Vinciguerra R, Seiler T, et al. Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 2009;116:369-78.
  11. Hafezi F, Wiltfang R, Kanellopoulos J, Seiler T. Corneal collagen cross-linking with riboflavin/UVA for the treatment of induced keratectasia after laser in situ keratomileusis. J Cat Refract Surg 2007;33:2035-40.
  12. Vinciguerra P, Camesasca FI, Albe E, Trazza S. Corneal collagen cross-linking for ectasia after excimer laser refractive surgery: 1-year results. J Refract Surg 2009;1-12.
  13. Schnitzler E, Sporl E, Seiler T. Irradiation of cornea with ultra violet light and riboflavin administration as a new treatment for erosive corneal processes, preliminary results in four patients. Klin Monatsbl Augenheilkd 2000;217:190-3.
  14. Schrier A, Greebel G, Attia H, Trokel S, Smith EF. In vitro antimicrobial efficacy of riboflavin and ultraviolet light on Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa. J Refract Surg 2009;25:S799-802.
  15. Wollensak G, Aurich H, Wirbelauer C, Pham DT. Potential use of riboflavin/UVA cross-linking in bullous keratopathy. Ophthalmic Res 2009;41:114-7.
  16. Ehlers N, Hjortdal J, Nielsen K, Søndergaard A. Riboflavin-UVA treatment in the management of edemaandnonhealing ulcers of thec ornea. J Refract Surg 2009;25:S803-6.
  17. Ehlers N, Hjortdal J. Riboflavin-ultraviolet light induced cross-linking in endothelial decompensation. Acta Ophthalmol 2008;86:549-51.
  18. Zamora KV, Males JJ. Polymicrobial keratitis after a collagen cross-linking procedure with postoperative use of a contact lens: A case report. Cornea 2009;28:474-6.
  19. Krueger RR, Ramos-Esteban JC, Kanellopoulos AJ. Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullous keratopathy: Laboratory investigation and first clinical case. J Refract Surg 2008;24:S730-6.
  20. Iseli HP, Thiel MA, Hafezi F, Kampmeier J, Seiler T. UltravioletA/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts. Cornea 2008;27:590-4.
  21. Coskunseven E, Jankov MR 2nd, Hafezi F, Atun S, Arslan E, Middle East African Journal of Ophthalmology, Volume 17, Number 1, January - March 2010 27Jankov II, et al.: Corneal Collagen Cross-linking Kymionis GD. Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen cross-linking for keratoconus. Cataract Refract Surg 2009;35:2084-91.
  22. Kamburoglu G, Ertan A. Intacs implantation with sequential collagen cross-linking treatment in postoperative LASIK ectasia. J Refract Surg 2008;24:S726-9.
  23. Chan CC, Sharma M, Wachler BS. Effect of implantation of inferior-segment Intacs with and without C3-R on keratoconus. J Cataract Refract Surg 2007;33:75- 80.
  24. Kanellopoulos AJ, Binder PS. Collagen cross-linking (CCL) with sequential topography- guided PRK: A temporizing alternative for keratoconusto penetrating keratoplasty. Cornea 2007;26:891-5.
  25. Kymionis GD, Kontadakis GA, Kounis GA, Portaliou DM, Karavitaki AE, Magarakis M, et al. Simultaneous topography guided PRK followed by corneal collagen cross- linking for keratoconus. J Refract Surg 2009;25:S807-11.
  26. Raiskup F, Hoyer A, Spoerl E. Permanent corneal haze after riboflavin-UVA-induced cross- linking in keratoconus. J Refract Surg 2009;25:S824-8.
  27. Kymionis GD, Bouzoukis DI, Diakonis VF, Portaliou DM, Pallikaris AI, Yoo SH. Diffuse lamellar keratitis after corneal cross-linking in a patient with post-laser in situ keratomileusis corneal ectasia. J Cataract Refract Surg 2007;33:2135-7.
  28. Kymionis GD, Portaliou DM, Bouzoukis DI, Suh LH, Pallikaris AI, Markomanolakis M, et al. Herpetic keratitis with iritis after corneal cross-linking with riboflavin and ultraviolet A for keratoconus. J Cataract Refract Surg 2007;33:1982-4.
  29. Koppen C, Vryghem JC, Gobin L, Tassignon MJ. Keratitis and corneal scarring after UVA/riboflavin cross-linking
  30. Kathleen Loouden, Corneal Cross-Linking in Children With Keratoconus Improves Visual Acuity, American Academy of Ophthalmology (AAO) and Middle East Africa Council of Ophthalmology (MEACO) 2010 Joint Annual Meeting
  31. Wollensak G, Spoerl E, Reber F, Seiler T. Keratocyte cytotoxicity of riboflavin/UVA- treatment in vitro. Eye 2004;:1-5.
  32. Wollensak G, Spoerl E, Wilsch M, Seiler T. Keratocyte apoptosis after corneal collagen cross- linking using Riboflavin/UVA treatment. Cornea 2004;23:43-9.
  33. Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin- ultraviolet: A treatment in the rabbit. J Cataract Refract Surg 2003;29:1786- 90.
  34. Seiler T, Hafezi F. Corneal cross-linking-induced stromal demarcation line. Cornea 2006;25:1057-9.
  35. Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C, et al. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: Ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea 2007;26:390-7.
  36. Eberhard Spoerl, PhD,* Michael Mrochen, PhD,† David Sliney, PhD, Stephen Trokel, MD,∞ and Theo Seiler, MD, PhD† Safety of UVA-Riboflavin Cross-Linking of Cornea Cornea Volume 26, Number 4, May 200714
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.